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SMILES: COc1ccc(cn1)[C@@H]([C@H](C)Nc1nn(C)c(=O)c2ccccc12)N(C)C

InChI Key: InChIKey=QMFNQKCXJDXABB-SCLBCKFNSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311482   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311482
PNG
(CHEM-US-00188 | US10155764, Example 62)
Show SMILES COc1ccc(cn1)[C@@H]([C@H](C)Nc1nn(C)c(=O)c2ccccc12)N(C)C |r|
Show InChI InChI=1S/C20H25N5O2/c1-13(18(24(2)3)14-10-11-17(27-5)21-12-14)22-19-15-8-6-7-9-16(15)20(26)25(4)23-19/h6-13,18H,1-5H3,(H,22,23)/t13-,18+/m0/s1
PDB
MMDB

NCI pathway
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KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a 63n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair