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SMILES: CC(Nc1nn(C)c(=O)c2cccnc12)C(N(C)C)c1cn(C)nn1

InChI Key: InChIKey=LQYSEWMBWOBATB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311500   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311500
PNG
(CHEM-US-00212 | US10155764, Example 75)
Show SMILES CC(Nc1nn(C)c(=O)c2cccnc12)C(N(C)C)c1cn(C)nn1
Show InChI InChI=1S/C16H22N8O/c1-10(14(22(2)3)12-9-23(4)21-19-12)18-15-13-11(7-6-8-17-13)16(25)24(5)20-15/h6-10,14H,1-5H3,(H,18,20)
PDB
MMDB

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KEGG

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PC cid
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UniChem
US Patent
n/an/a 130n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair