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SMILES: C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(cc1)C(=O)N1CCCC1

InChI Key: InChIKey=LDTRIOXBEPRMGY-HRAATJIYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311508   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311508
PNG
(CHEM-US-00228 | US10155764, Example 83)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(cc1)C(=O)N1CCCC1 |r|
Show InChI InChI=1S/C24H30N6O2/c1-16(26-22-20-19(8-7-13-25-20)24(32)29(4)27-22)21(28(2)3)17-9-11-18(12-10-17)23(31)30-14-5-6-15-30/h7-13,16,21H,5-6,14-15H2,1-4H3,(H,26,27)/t16-,21+/m0/s1
PDB
MMDB

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PC cid
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UniChem
US Patent
n/an/a 71n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair