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SMILES: NCCNc1ccn2ncc(C(=O)Nc3cn(nc3C(N)=O)-c3cccnc3)c2n1

InChI Key: InChIKey=QXVLFHHSHJGJEC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311525   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM311525
PNG
(5-[(2- aminoethyl)amino]-N- (3-carbamoyl-1-pyridin...)
Show SMILES NCCNc1ccn2ncc(C(=O)Nc3cn(nc3C(N)=O)-c3cccnc3)c2n1
Show InChI InChI=1S/C18H18N10O2/c19-4-6-22-14-3-7-27-17(25-14)12(9-23-27)18(30)24-13-10-28(26-15(13)16(20)29)11-2-1-5-21-8-11/h1-3,5,7-10H,4,6,19H2,(H2,20,29)(H,22,25)(H,24,30)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.700n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...

US Patent US10155765 (2018)


BindingDB Entry DOI: 10.7270/Q21V5H2J
More data for this
Ligand-Target Pair