null
SMILES: Oc1cc2cccnc2[nH]c1=O
InChI Key: InChIKey=IKJDIDUPEGBVKA-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D-amino-acid oxidase (Homo sapiens (Human)) | BDBM31164 (naphthyridinone analog.,18) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | 8.5 | 22 |
Pfizer | Assay Description Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox... | J Med Chem 52: 3576-85 (2009) Article DOI: 10.1021/jm900128w BindingDB Entry DOI: 10.7270/Q2CZ35HM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-amino-acid oxidase (Rattus norvegicus (rat)) | BDBM31164 (naphthyridinone analog.,18) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox... | J Med Chem 52: 3576-85 (2009) Article DOI: 10.1021/jm900128w BindingDB Entry DOI: 10.7270/Q2CZ35HM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-amino-acid oxidase (Homo sapiens (Human)) | BDBM31164 (naphthyridinone analog.,18) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Binding affinity and kinetics were measured using biotinylated recombinant human DAAO bound to a Neutravidin surface in a Biacore binding assay. A cu... | J Med Chem 52: 3576-85 (2009) Article DOI: 10.1021/jm900128w BindingDB Entry DOI: 10.7270/Q2CZ35HM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-aspartate oxidase (Homo sapiens (Human)) | BDBM31164 (naphthyridinone analog.,18) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >7.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-aspartic acid was linke... | J Med Chem 52: 3576-85 (2009) Article DOI: 10.1021/jm900128w BindingDB Entry DOI: 10.7270/Q2CZ35HM | |||||||||||
More data for this Ligand-Target Pair |