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BDBM311752 Ex. Cpd. 206

SMILES: COCc1ccc(NC(=O)c2c(C#CCN3CCOCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1F

InChI Key:

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 311752   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311752
PNG
(Ex. Cpd. 206)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCN3CCOCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1F
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent




US Patent US10155768 (2018)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2X350J3
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM311752
PNG
(Ex. Cpd. 206)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCN3CCOCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1F
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 5.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent




US Patent US10155768 (2018)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2X350J3
More data for this
Ligand-Target Pair
RET kinase mutant (V804L)


(Homo sapiens (Human))
BDBM311752
PNG
(Ex. Cpd. 206)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCN3CCOCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1F
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent




US Patent US10155768 (2018)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2X350J3
More data for this
Ligand-Target Pair