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BDBM311808 2-(Difluoromethyl)-7-(4-fluorophenyl)-8-(7-methyl-1H-indazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridine::US10155769, Example 46

SMILES: Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)F)-c1ccc(F)cc1

InChI Key: InChIKey=XZPCBPSVTOHPGN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311808   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM311808
PNG
(2-(Difluoromethyl)-7-(4-fluorophenyl)-8-(7-methyl-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C21H14F3N5/c1-11-8-13(9-14-10-25-27-18(11)14)17-16(12-2-4-15(22)5-3-12)6-7-29-21(17)26-20(28-29)19(23)24/h2-10,19H,1H3,(H,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0320n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...

US Patent US10155769 (2018)


BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair