BDBM31198 spiro-oxindole, 4
SMILES: CC(C)(C)C[C@H]1N[C@H]([C@H](c2cccc(Cl)c2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1
InChI Key: InChIKey=GXAPJIXXSLQQBJ-ZTVFFDQVSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM31198 (spiro-oxindole, 4) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 13 | -10.7 | n/a | n/a | n/a | n/a | n/a | 7.5 | 23 |
University of Michigan | Assay Description The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an... | J Med Chem 49: 3432-5 (2006) Article DOI: 10.1021/jm051122a BindingDB Entry DOI: 10.7270/Q24F1P3B | |||||||||||
More data for this Ligand-Target Pair |