BDBM312136 4-bromo-6-hydroxy-2-(4-hydroxyphenyl)-1-oxo-1,2-dihydroisoquinoline-8-carbonitrile ::US9604931, 14k::US9623021, Compound 14l

SMILES: Oc1ccc(cc1)-n1cc(Br)c2cc(O)cc(C#N)c2c1=O

InChI Key: InChIKey=IYKXSJBWAQMFEC-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 312136   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor beta (Homo sapiens (Human))	BDBM312136 (4-bromo-6-hydroxy-2-(4-hydroxyphenyl)-1-oxo-1,2-di...) Show SMILES Oc1ccc(cc1)-n1cc(Br)c2cc(O)cc(C#N)c2c1=O Show InChI InChI=1S/C16H9BrN2O3/c17-14-8-19(10-1-3-11(20)4-2-10)16(22)15-9(7-18)5-12(21)6-13(14)15/h1-6,8,20-21H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTX, Inc. US Patent					Assay Description Recombinant ER-α or ER-β ligand binding domain (LBD) was combined with [3H]E2 (PerkinElmer, Waltham, Mass.) in buffer A (10 mM Tris, pH 7.4...				US Patent US9623021 (2017) BindingDB Entry DOI: 10.7270/Q20C4XV9
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR2 (Homo sapiens (Human))	BDBM312136 (4-bromo-6-hydroxy-2-(4-hydroxyphenyl)-1-oxo-1,2-di...) Show SMILES Oc1ccc(cc1)-n1cc(Br)c2cc(O)cc(C#N)c2c1=O Show InChI InChI=1S/C16H9BrN2O3/c17-14-8-19(10-1-3-11(20)4-2-10)16(22)15-9(7-18)5-12(21)6-13(14)15/h1-6,8,20-21H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc.; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS US Patent					Assay Description Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...				US Patent US9604931 (2017) BindingDB Entry DOI: 10.7270/Q23N25FR
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM312136 (4-bromo-6-hydroxy-2-(4-hydroxyphenyl)-1-oxo-1,2-di...) Show SMILES Oc1ccc(cc1)-n1cc(Br)c2cc(O)cc(C#N)c2c1=O Show InChI InChI=1S/C16H9BrN2O3/c17-14-8-19(10-1-3-11(20)4-2-10)16(22)15-9(7-18)5-12(21)6-13(14)15/h1-6,8,20-21H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	76	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTX, Inc. US Patent					Assay Description Recombinant ER-α or ER-β ligand binding domain (LBD) was combined with [3H]E2 (PerkinElmer, Waltham, Mass.) in buffer A (10 mM Tris, pH 7.4...				US Patent US9623021 (2017) BindingDB Entry DOI: 10.7270/Q20C4XV9
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR1 (Homo sapiens (Human))	BDBM312136 (4-bromo-6-hydroxy-2-(4-hydroxyphenyl)-1-oxo-1,2-di...) Show SMILES Oc1ccc(cc1)-n1cc(Br)c2cc(O)cc(C#N)c2c1=O Show InChI InChI=1S/C16H9BrN2O3/c17-14-8-19(10-1-3-11(20)4-2-10)16(22)15-9(7-18)5-12(21)6-13(14)15/h1-6,8,20-21H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>394	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc.; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS US Patent					Assay Description Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...				US Patent US9604931 (2017) BindingDB Entry DOI: 10.7270/Q23N25FR
					More data for this Ligand-Target Pair