BDBM31275 Chalcone derivative, B-1

SMILES: OC(=O)COc1ccc(cc1)C(=O)\C=C\c1ccc(Cl)c(Cl)c1

InChI Key: InChIKey=DCUDBWMZJBOZAB-KRXBUXKQSA-N

Data: 1 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 31275   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM31275 (Chalcone derivative, B-1) Show SMILES OC(=O)COc1ccc(cc1)C(=O)\C=C\c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H12Cl2O4/c18-14-7-1-11(9-15(14)19)2-8-16(20)12-3-5-13(6-4-12)23-10-17(21)22/h1-9H,10H2,(H,21,22)/b8-2+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.50E+5	n/a	n/a	n/a	7.4	23
Max Planck Institute					Assay Description NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...				Biochemistry 40: 336-44 (2001) Article DOI: 10.1021/bi000930v BindingDB Entry DOI: 10.7270/Q2GQ6W3K
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM31275 (Chalcone derivative, B-1) Show SMILES OC(=O)COc1ccc(cc1)C(=O)\C=C\c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H12Cl2O4/c18-14-7-1-11(9-15(14)19)2-8-16(20)12-3-5-13(6-4-12)23-10-17(21)22/h1-9H,10H2,(H,21,22)/b8-2+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.17E+5	n/a	n/a	n/a	n/a	7.4	23
Max Planck Institute					Assay Description Interference of the p53-MDM2 binding by test compounds was measured in a 96-well polypropylene round-bottom microtiter plate (Costar, Serocluster). H...				Biochemistry 40: 336-44 (2001) Article DOI: 10.1021/bi000930v BindingDB Entry DOI: 10.7270/Q2GQ6W3K
					More data for this Ligand-Target Pair