BDBM31276 Chalcone derivative, C

SMILES: CC(C)(Oc1ccc(\C=C\C(=O)c2ccc(Cl)cc2)cc1)C(O)=O

InChI Key: InChIKey=AICGQCAOHPDKQH-LFYBBSHMSA-N

Data: 1 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 31276   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM31276 (Chalcone derivative, C) Show SMILES CC(C)(Oc1ccc(\C=C\C(=O)c2ccc(Cl)cc2)cc1)C(O)=O Show InChI InChI=1S/C19H17ClO4/c1-19(2,18(22)23)24-16-10-3-13(4-11-16)5-12-17(21)14-6-8-15(20)9-7-14/h3-12H,1-2H3,(H,22,23)/b12-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.44E+5	n/a	n/a	n/a	7.4	23
Max Planck Institute					Assay Description NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...				Biochemistry 40: 336-44 (2001) Article DOI: 10.1021/bi000930v BindingDB Entry DOI: 10.7270/Q2GQ6W3K
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM31276 (Chalcone derivative, C) Show SMILES CC(C)(Oc1ccc(\C=C\C(=O)c2ccc(Cl)cc2)cc1)C(O)=O Show InChI InChI=1S/C19H17ClO4/c1-19(2,18(22)23)24-16-10-3-13(4-11-16)5-12-17(21)14-6-8-15(20)9-7-14/h3-12H,1-2H3,(H,22,23)/b12-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+5	n/a	n/a	n/a	n/a	7.4	23
Max Planck Institute					Assay Description Interference of the p53-MDM2 binding by test compounds was measured in a 96-well polypropylene round-bottom microtiter plate (Costar, Serocluster). H...				Biochemistry 40: 336-44 (2001) Article DOI: 10.1021/bi000930v BindingDB Entry DOI: 10.7270/Q2GQ6W3K
					More data for this Ligand-Target Pair