BindingDB logo
myBDB logout

null

SMILES: CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3c(NC4CC4)nccc23)C1=O

InChI Key: InChIKey=UMNOVBSWYKEADA-QHCPKHFHSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 312840   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))		BDBM312840
PNG
(4-(cyclopropylamino)-1-[3- [2-[(3R)-3-hydroxy-1-me...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3c(NC4CC4)nccc23)C1=O |r|
Show InChI InChI=1S/C23H22N6O3/c1-28-12-10-23(32,22(28)31)9-7-14-3-2-4-16(13-14)29-17-8-11-25-21(26-15-5-6-15)18(17)19(27-29)20(24)30/h2-4,8,11,13,15,32H,5-6,10,12H2,1H3,(H2,24,30)(H,25,26)/t23-/m0/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 0.110n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...

US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair