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SMILES: CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(cc23)C(N)=O)C1=O

InChI Key: InChIKey=HRHTWWGKEMLIKW-QFIPXVFZSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 312888   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))		BDBM312888
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(cc23)C(N)=O)C1=O |r|
Show InChI InChI=1S/C22H19N5O4/c1-26-10-8-22(31,21(26)30)7-5-13-3-2-4-14(11-13)17-16-12-15(18(23)28)6-9-27(16)20(25-17)19(24)29/h2-4,6,9,11-12,31H,8,10H2,1H3,(H2,23,28)(H2,24,29)/t22-/m0/s1
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PC cid
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US Patent
 0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...

US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair