BindingDB logo
myBDB logout

null

SMILES: Cc1ccc2c(nn(Cc3ccc(C)c(F)c3F)c2n1)-c1nnc2c(NC(=O)C2(C)C)n1

InChI Key: InChIKey=FVJSIPAERGJFIF-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 312961   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM312961
PNG
(3-[1-(2,3-Difluoro-4-methylbenzyl)-6-methyl-1H-pyr...)
Show SMILES Cc1ccc2c(nn(Cc3ccc(C)c(F)c3F)c2n1)-c1nnc2c(NC(=O)C2(C)C)n1
Show InChI InChI=1S/C22H19F2N7O/c1-10-5-7-12(15(24)14(10)23)9-31-20-13(8-6-11(2)25-20)16(30-31)18-26-19-17(28-29-18)22(3,4)21(32)27-19/h5-8H,9H2,1-4H3,(H,26,27,29,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.650n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...

US Patent US9605008 (2017)


BindingDB Entry DOI: 10.7270/Q2DZ0BC2
More data for this
Ligand-Target Pair