BDBM313532 N-(3-(2-((2- hydroxyethyl)amino)-6- (3-methoxyoxetan-3- yl)pyridin-4-yl)-4- methylphenyl)-3- (trifluoromethyl)benzamide::US10167279, Example 153

SMILES: COC1(COC1)c1cc(cc(NCCO)n1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C

InChI Key: InChIKey=HHYBGGHNCKGCTI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 313532   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM313532 (N-(3-(2-((2- hydroxyethyl)amino)-6- (3-methoxyoxet...) Show SMILES COC1(COC1)c1cc(cc(NCCO)n1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C26H26F3N3O4/c1-16-6-7-20(31-24(34)17-4-3-5-19(10-17)26(27,28)29)13-21(16)18-11-22(25(35-2)14-36-15-25)32-23(12-18)30-8-9-33/h3-7,10-13,33H,8-9,14-15H2,1-2H3,(H,30,32)(H,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...				US Patent US10167279 (2019) BindingDB Entry DOI: 10.7270/Q2W0981V
					More data for this Ligand-Target Pair