BDBM313568 N-(3-(2- (hydroxymethyl)- 2-methyl-3-oxo-5- (tetrahydro-2H-pyran-4- yl)-3,4-dihydro-2H-benzo [b][1,4]oxazin-7-yl)-4- methylphenyl)-4- (trifluoromethyl) picolinamide::US10167279, Example 192::US10167279, Example 193::US10167279, Example 194

SMILES: Cc1ccc(NC(=O)c2cc(ccn2)C(F)(F)F)cc1-c1cc2OC(C)(CO)C(=O)Nc2c(c1)C1CCOCC1

InChI Key: InChIKey=CVCWPOXZQKWUDE-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 313568   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM313568 (N-(3-(2- (hydroxymethyl)- 2-methyl-3-oxo-5- (tetra...) Show SMILES Cc1ccc(NC(=O)c2cc(ccn2)C(F)(F)F)cc1-c1cc2OC(C)(CO)C(=O)Nc2c(c1)C1CCOCC1 Show InChI InChI=1S/C29H28F3N3O5/c1-16-3-4-20(34-26(37)23-13-19(5-8-33-23)29(30,31)32)14-21(16)18-11-22(17-6-9-39-10-7-17)25-24(12-18)40-28(2,15-36)27(38)35-25/h3-5,8,11-14,17,36H,6-7,9-10,15H2,1-2H3,(H,34,37)(H,35,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...				US Patent US10167279 (2019) BindingDB Entry DOI: 10.7270/Q2W0981V
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM313568 (N-(3-(2- (hydroxymethyl)- 2-methyl-3-oxo-5- (tetra...) Show SMILES Cc1ccc(NC(=O)c2cc(ccn2)C(F)(F)F)cc1-c1cc2OC(C)(CO)C(=O)Nc2c(c1)C1CCOCC1 Show InChI InChI=1S/C29H28F3N3O5/c1-16-3-4-20(34-26(37)23-13-19(5-8-33-23)29(30,31)32)14-21(16)18-11-22(17-6-9-39-10-7-17)25-24(12-18)40-28(2,15-36)27(38)35-25/h3-5,8,11-14,17,36H,6-7,9-10,15H2,1-2H3,(H,34,37)(H,35,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...				US Patent US10167279 (2019) BindingDB Entry DOI: 10.7270/Q2W0981V
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM313568 (N-(3-(2- (hydroxymethyl)- 2-methyl-3-oxo-5- (tetra...) Show SMILES Cc1ccc(NC(=O)c2cc(ccn2)C(F)(F)F)cc1-c1cc2OC(C)(CO)C(=O)Nc2c(c1)C1CCOCC1 Show InChI InChI=1S/C29H28F3N3O5/c1-16-3-4-20(34-26(37)23-13-19(5-8-33-23)29(30,31)32)14-21(16)18-11-22(17-6-9-39-10-7-17)25-24(12-18)40-28(2,15-36)27(38)35-25/h3-5,8,11-14,17,36H,6-7,9-10,15H2,1-2H3,(H,34,37)(H,35,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...				US Patent US10167279 (2019) BindingDB Entry DOI: 10.7270/Q2W0981V
					More data for this Ligand-Target Pair