BDBM313580 N-(3-(2- (hydroxymethyl)-2- methyl-3-oxo-8- (tetrahydro-2H- pyran-4-yl)-3,4-dihydro- 2H- benzo[b][1,4]oxazin-6- yl)-4-methylphenyl)-5- (trifluoromethyl) pyridazine-3-carboxamide::US10167279, Example 204

SMILES: Cc1ccc(NC(=O)c2cc(cnn2)C(F)(F)F)cc1-c1cc2NC(=O)C(C)(CO)Oc2c(c1)C1CCOCC1

InChI Key: InChIKey=FJKDWRMOEUEOSF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 313580   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM313580 (N-(3-(2- (hydroxymethyl)-2- methyl-3-oxo-8- (tetra...) Show SMILES Cc1ccc(NC(=O)c2cc(cnn2)C(F)(F)F)cc1-c1cc2NC(=O)C(C)(CO)Oc2c(c1)C1CCOCC1 Show InChI InChI=1S/C28H27F3N4O5/c1-15-3-4-19(33-25(37)23-11-18(13-32-35-23)28(29,30)31)12-20(15)17-9-21(16-5-7-39-8-6-16)24-22(10-17)34-26(38)27(2,14-36)40-24/h3-4,9-13,16,36H,5-8,14H2,1-2H3,(H,33,37)(H,34,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...				US Patent US10167279 (2019) BindingDB Entry DOI: 10.7270/Q2W0981V
					More data for this Ligand-Target Pair