BDBM313604 5-chloro-N-(3-(6- ethoxy-5-(tetrahydro- 2H-pyran-4-yl) pyridazin-3-yl)-4- methylphenyl)-4- (trifluoromethyl) picolinamide::US10167279, Example 228

SMILES: CCOc1nnc(cc1C1CCOCC1)-c1cc(NC(=O)c2cc(c(Cl)cn2)C(F)(F)F)ccc1C

InChI Key: InChIKey=UORSDJKSEPMQEF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 313604   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM313604 (5-chloro-N-(3-(6- ethoxy-5-(tetrahydro- 2H-pyran-4...) Show SMILES CCOc1nnc(cc1C1CCOCC1)-c1cc(NC(=O)c2cc(c(Cl)cn2)C(F)(F)F)ccc1C Show InChI InChI=1S/C25H24ClF3N4O3/c1-3-36-24-18(15-6-8-35-9-7-15)11-21(32-33-24)17-10-16(5-4-14(17)2)31-23(34)22-12-19(25(27,28)29)20(26)13-30-22/h4-5,10-13,15H,3,6-9H2,1-2H3,(H,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...				US Patent US10167279 (2019) BindingDB Entry DOI: 10.7270/Q2W0981V
					More data for this Ligand-Target Pair