BDBM313608 N-(3-(6-ethoxy-5- (tetrahydro-2H-pyran-4- yl)pyridazin-3-yl)-4- methylphenyl)-5- (trifluoromethyl) pyrazine-2-carboxamide::US10167279, Example 232

SMILES: CCOc1nnc(cc1C1CCOCC1)-c1cc(NC(=O)c2cc(ncn2)C(F)(F)F)ccc1C

InChI Key: InChIKey=PCULKHIWACIBFE-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 313608   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM313608 (N-(3-(6-ethoxy-5- (tetrahydro-2H-pyran-4- yl)pyrid...) Show SMILES CCOc1nnc(cc1C1CCOCC1)-c1cc(NC(=O)c2cc(ncn2)C(F)(F)F)ccc1C Show InChI InChI=1S/C24H24F3N5O3/c1-3-35-23-18(15-6-8-34-9-7-15)11-19(31-32-23)17-10-16(5-4-14(17)2)30-22(33)20-12-21(24(25,26)27)29-13-28-20/h4-5,10-13,15H,3,6-9H2,1-2H3,(H,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...				US Patent US10167279 (2019) BindingDB Entry DOI: 10.7270/Q2W0981V
					More data for this Ligand-Target Pair