BDBM313613 N-(3-(6-ethoxy-5- (tetrahydro-2H-pyran-4- yl)pyridazin-3-yl)-4- methylphenyl)-2- (2-fluoropropan-2-yl) isonicotinamide::US10167279, Example 238

SMILES: CCOc1nnc(cc1C1CCOCC1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)F)ccc1C

InChI Key: InChIKey=VTIVWBKXOXDVJB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 313613   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM313613 (N-(3-(6-ethoxy-5- (tetrahydro-2H-pyran-4- yl)pyrid...) Show SMILES CCOc1nnc(cc1C1CCOCC1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)F)ccc1C Show InChI InChI=1S/C27H31FN4O3/c1-5-35-26-22(18-9-12-34-13-10-18)16-23(31-32-26)21-15-20(7-6-17(21)2)30-25(33)19-8-11-29-24(14-19)27(3,4)28/h6-8,11,14-16,18H,5,9-10,12-13H2,1-4H3,(H,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...				US Patent US10167279 (2019) BindingDB Entry DOI: 10.7270/Q2W0981V
					More data for this Ligand-Target Pair