BDBM313650 (R)-N-(3-(2-(2,3- dihydroxypropoxy)-6- (tetrahydro-2H-pyran-4- yl)pyridin-4-yl)-4- methylphenyl)-6- (trifluoromethyl) pyrimidine-4- carboxamide::US10167279, Example 276

SMILES: Cc1ccc(NC(=O)c2cc(ncn2)C(F)(F)F)cc1-c1cc(OC[C@H](O)CO)nc(c1)C1CCOCC1

InChI Key: InChIKey=CLBAVQUKLIDHCF-LJQANCHMSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 313650   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM313650 ((R)-N-(3-(2-(2,3- dihydroxypropoxy)-6- (tetrahydro...) Show SMILES Cc1ccc(NC(=O)c2cc(ncn2)C(F)(F)F)cc1-c1cc(OC[C@H](O)CO)nc(c1)C1CCOCC1 |r| Show InChI InChI=1S/C26H27F3N4O5/c1-15-2-3-18(32-25(36)22-11-23(26(27,28)29)31-14-30-22)10-20(15)17-8-21(16-4-6-37-7-5-16)33-24(9-17)38-13-19(35)12-34/h2-3,8-11,14,16,19,34-35H,4-7,12-13H2,1H3,(H,32,36)/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...				US Patent US10167279 (2019) BindingDB Entry DOI: 10.7270/Q2W0981V
					More data for this Ligand-Target Pair