BDBM313687 N-(4-methyl-3-(5-tetrahydro-2H-pyran-4-yl-6-((tetrahydro-2H-pyran-4-yl)oxy)pyridazin-3-yl)phenyl)-2-(trifluoromethyl)isonicotinamide::US10167279, Example 313

SMILES: Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc(C2CCOCC2)c(OC2CCOCC2)nn1

InChI Key: InChIKey=OBJXEZQUWRAXFQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 313687   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM313687 (N-(4-methyl-3-(5-tetrahydro-2H-pyran-4-yl-6-((tetr...) Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc(C2CCOCC2)c(OC2CCOCC2)nn1 Show InChI InChI=1S/C28H29F3N4O4/c1-17-2-3-20(33-26(36)19-4-9-32-25(14-19)28(29,30)31)15-22(17)24-16-23(18-5-10-37-11-6-18)27(35-34-24)39-21-7-12-38-13-8-21/h2-4,9,14-16,18,21H,5-8,10-13H2,1H3,(H,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...				US Patent US10167279 (2019) BindingDB Entry DOI: 10.7270/Q2W0981V
					More data for this Ligand-Target Pair