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SMILES: NC(=O)[C@@H]1CCCCCC(=O)C(Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)CC(=O)[C@H](CC2CCCCC2)NC(=O)\C=C\C(=O)N1

InChI Key: InChIKey=PHAMAAGUYZXWJI-XHUQNQKFSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 314088   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin-degrading enzyme


(Homo sapiens (Human))		BDBM314088
PNG
(US9610322, 3a (cis olefin))
Show SMILES NC(=O)[C@@H]1CCCCCC(=O)C(Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)CC(=O)[C@H](CC2CCCCC2)NC(=O)\C=C\C(=O)N1 |r,t:56|
Show InChI InChI=1S/C46H60N4O7/c47-45(56)37-19-11-4-12-20-40(51)38(29-33-21-23-35(24-22-33)44(55)34-17-9-3-10-18-34)50-46(57)36(27-31-13-5-1-6-14-31)30-41(52)39(28-32-15-7-2-8-16-32)49-43(54)26-25-42(53)48-37/h3,9-10,17-18,21-26,31-32,36-39H,1-2,4-8,11-16,19-20,27-30H2,(H2,47,56)(H,48,53)(H,49,54)(H,50,57)/b26-25+/t36-,37+,38?,39+/m1/s1
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KEGG

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US Patent
n/an/a>2.00E+4n/an/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...

US Patent US9610322 (2017)


BindingDB Entry DOI: 10.7270/Q29Z970C
More data for this
Ligand-Target Pair