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SMILES: NC(=C)CC[C@@H]1NC(=O)\C=C\C(=O)N[C@@H](CCCCCC(=O)C(Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)CC1=O)C(N)=O

InChI Key: InChIKey=OPIMKBVXMOFIMR-VRQXRQBFSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 314096   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin-degrading enzyme


(Homo sapiens (Human))		BDBM314096
PNG
(US9610322, 6b (trans olefin))
Show SMILES NC(=C)CC[C@@H]1NC(=O)\C=C\C(=O)N[C@@H](CCCCCC(=O)C(Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)CC1=O)C(N)=O |r,t:9|
Show InChI InChI=1S/C43H55N5O7/c1-28(44)17-22-34-38(50)27-33(25-29-11-5-2-6-12-29)43(55)48-36(26-30-18-20-32(21-19-30)41(53)31-13-7-3-8-14-31)37(49)16-10-4-9-15-35(42(45)54)47-40(52)24-23-39(51)46-34/h3,7-8,13-14,18-21,23-24,29,33-36H,1-2,4-6,9-12,15-17,22,25-27,44H2,(H2,45,54)(H,46,51)(H,47,52)(H,48,55)/b24-23+/t33-,34+,35+,36?/m1/s1
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KEGG

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US Patent
n/an/a 60n/an/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...

US Patent US9610322 (2017)


BindingDB Entry DOI: 10.7270/Q29Z970C
More data for this
Ligand-Target Pair