BDBM31543 pyrazolo[4,3-h]quinazoline-3-carboxamide, 26
SMILES: Cn1nc(C(N)=O)c2c1-c1nc(Nc3ccccc3)ncc1CC2(C)C
InChI Key: InChIKey=ZLUXKRIOOANRPI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-Dependent Kinase 2 (CDK2) (Homo sapiens (Human)) | BDBM31543 (pyrazolo[4,3-h]quinazoline-3-carboxamide, 26) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Nerviano Medical Sciences Srl | Assay Description The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat... | J Med Chem 52: 5152-63 (2009) Article DOI: 10.1021/jm9006559 BindingDB Entry DOI: 10.7270/Q2JH3JJP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Aurora kinase A (Homo sapiens (Human)) | BDBM31543 (pyrazolo[4,3-h]quinazoline-3-carboxamide, 26) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Nerviano Medical Sciences Srl | Assay Description The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat... | J Med Chem 52: 5152-63 (2009) Article DOI: 10.1021/jm9006559 BindingDB Entry DOI: 10.7270/Q2JH3JJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK6/CycD3 (Homo sapiens (Human)) | BDBM31543 (pyrazolo[4,3-h]quinazoline-3-carboxamide, 26) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangnan University Curated by ChEMBL | Assay Description Inhibition of CDK6/Cyclin D3 (unknown origin) using FAM-labeled peptide as substrate after 40 mins | Eur J Med Chem 157: 935-945 (2018) Article DOI: 10.1016/j.ejmech.2018.08.043 BindingDB Entry DOI: 10.7270/Q23T9KXC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 2 (CDK2) (Homo sapiens (Human)) | BDBM31543 (pyrazolo[4,3-h]quinazoline-3-carboxamide, 26) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangnan University Curated by ChEMBL | Assay Description Inhibition of CDK2/Cyclin A2 (unknown origin) using FAM-labeled peptide as substrate after 40 mins | Eur J Med Chem 157: 935-945 (2018) Article DOI: 10.1016/j.ejmech.2018.08.043 BindingDB Entry DOI: 10.7270/Q23T9KXC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
CDK4/Cyclin D3 (Homo sapiens (Human)) | BDBM31543 (pyrazolo[4,3-h]quinazoline-3-carboxamide, 26) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangnan University Curated by ChEMBL | Assay Description Inhibition of CDK4/Cyclin D3 (unknown origin) using FAM-labeled peptide as substrate after 40 mins | Eur J Med Chem 157: 935-945 (2018) Article DOI: 10.1016/j.ejmech.2018.08.043 BindingDB Entry DOI: 10.7270/Q23T9KXC | |||||||||||
More data for this Ligand-Target Pair |