BDBM31589 triaryl imidazole, 1
SMILES: COc1ccc(cc1)-c1nc([nH]c1-c1ccc(OC)cc1)-c1cccs1
InChI Key: InChIKey=XBMULXNXJLWLLD-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM31589 (triaryl imidazole, 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs | Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Phosphodiesterase Type 10 (PDE10A) (Rattus norvegicus (rat)) | BDBM31589 (triaryl imidazole, 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |