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SMILES: Cn1cc(c(n1)-c1ccc(OCc2nc3ccccn3n2)cc1)-c1ccncc1

InChI Key: InChIKey=FOSALFAKSPTCPP-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 31607   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM31607
PNG
(methyl substituted pyrazole, 28)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2nc3ccccn3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C22H18N6O/c1-27-14-19(16-9-11-23-12-10-16)22(26-27)17-5-7-18(8-6-17)29-15-20-24-21-4-2-3-13-28(21)25-20/h2-14H,15H2,1H3
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PC cid
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Article
PubMed
n/an/a 3.40n/an/an/an/a7.523



Pfizer



Assay Description
PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...

J Med Chem 52: 5188-96 (2009)


Article DOI: 10.1021/jm900521k
BindingDB Entry DOI: 10.7270/Q290223B
More data for this
Ligand-Target Pair