BDBM316285 2-Dimethylamino-5-[6-(4-fluoro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzamide::US10294218, Example 113::US9617225, Example 113
SMILES: COc1cc(F)ccc1-c1cc(Nc2ccc(N(C)C)c(c2)C(N)=O)ncn1
InChI Key: InChIKey=MBCAOKHCWOIKOV-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-Dependent Kinase 9 (CDK9) (Homo sapiens (Human)) | BDBM316285 (2-Dimethylamino-5-[6-(4-fluoro-2-methoxy-phenyl)-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description The activity of the compounds described in the present invention can be determined by measuring the phosphorylation of a fluorescently-labeled peptid... | Bioorg Med Chem Lett 18: 1022-6 (2008) BindingDB Entry DOI: 10.7270/Q2RB76X4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 9 (Homo sapiens (Human)) | BDBM316285 (2-Dimethylamino-5-[6-(4-fluoro-2-methoxy-phenyl)-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
VIROSTATICS SRL US Patent | Assay Description The activity of the compounds described in the present invention can be determined by measuring the phosphorylation of a fluorescently-labeled peptid... | US Patent US9617225 (2017) BindingDB Entry DOI: 10.7270/Q29W0HK6 | |||||||||||
More data for this Ligand-Target Pair |