BDBM31637 tetrahydrobenzothiophene (THBT), 6
SMILES: CC1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O
InChI Key: InChIKey=OBHKTNMETRQPKN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM31637 (tetrahydrobenzothiophene (THBT), 6) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 501 | n/a | n/a | n/a | n/a | 7.5 | 23 |
GSK | Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive... | Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human)) | BDBM31637 (tetrahydrobenzothiophene (THBT), 6) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | 7.5 | 23 |
GSK | Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive... | Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |