BDBM316693 2-[(1-acryloylazetidin-3-yl)amino]-N-(propan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide::US9617258, Example 188

SMILES: CC(C)NC(=O)c1c[nH]c2ncc(NC3CN(C3)C(=O)C=C)nc12

InChI Key: InChIKey=JQSIDKLDARXUHP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 316693   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM316693 (2-[(1-acryloylazetidin-3-yl)amino]-N-(propan-2-yl)...) Show SMILES CC(C)NC(=O)c1c[nH]c2ncc(NC3CN(C3)C(=O)C=C)nc12 Show InChI InChI=1S/C16H20N6O2/c1-4-13(23)22-7-10(8-22)20-12-6-18-15-14(21-12)11(5-17-15)16(24)19-9(2)3/h4-6,9-10H,1,7-8H2,2-3H3,(H,17,18)(H,19,24)(H,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...				US Patent US9617258 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZWG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM316693 (2-[(1-acryloylazetidin-3-yl)amino]-N-(propan-2-yl)...) Show SMILES CC(C)NC(=O)c1c[nH]c2ncc(NC3CN(C3)C(=O)C=C)nc12 Show InChI InChI=1S/C16H20N6O2/c1-4-13(23)22-7-10(8-22)20-12-6-18-15-14(21-12)11(5-17-15)16(24)19-9(2)3/h4-6,9-10H,1,7-8H2,2-3H3,(H,17,18)(H,19,24)(H,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM316693 (2-[(1-acryloylazetidin-3-yl)amino]-N-(propan-2-yl)...) Show SMILES CC(C)NC(=O)c1c[nH]c2ncc(NC3CN(C3)C(=O)C=C)nc12 Show InChI InChI=1S/C16H20N6O2/c1-4-13(23)22-7-10(8-22)20-12-6-18-15-14(21-12)11(5-17-15)16(24)19-9(2)3/h4-6,9-10H,1,7-8H2,2-3H3,(H,17,18)(H,19,24)(H,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM316693 (2-[(1-acryloylazetidin-3-yl)amino]-N-(propan-2-yl)...) Show SMILES CC(C)NC(=O)c1c[nH]c2ncc(NC3CN(C3)C(=O)C=C)nc12 Show InChI InChI=1S/C16H20N6O2/c1-4-13(23)22-7-10(8-22)20-12-6-18-15-14(21-12)11(5-17-15)16(24)19-9(2)3/h4-6,9-10H,1,7-8H2,2-3H3,(H,17,18)(H,19,24)(H,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...				US Patent US9617258 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZWG
					More data for this Ligand-Target Pair