BDBM316773 2-[(1-acryloylpiperidin-4-yl)amino]-N-butyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide::US9617258, Example 269

SMILES: CCCCNC(=O)c1c[nH]c2ncc(NC3CCN(CC3)C(=O)C=C)nc12

InChI Key: InChIKey=DZQXKRVHAIUIAO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 316773   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM316773 (2-[(1-acryloylpiperidin-4-yl)amino]-N-butyl-5H-pyr...) Show SMILES CCCCNC(=O)c1c[nH]c2ncc(NC3CCN(CC3)C(=O)C=C)nc12 Show InChI InChI=1S/C19H26N6O2/c1-3-5-8-20-19(27)14-11-21-18-17(14)24-15(12-22-18)23-13-6-9-25(10-7-13)16(26)4-2/h4,11-13H,2-3,5-10H2,1H3,(H,20,27)(H,21,22)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...				US Patent US9617258 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZWG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM316773 (2-[(1-acryloylpiperidin-4-yl)amino]-N-butyl-5H-pyr...) Show SMILES CCCCNC(=O)c1c[nH]c2ncc(NC3CCN(CC3)C(=O)C=C)nc12 Show InChI InChI=1S/C19H26N6O2/c1-3-5-8-20-19(27)14-11-21-18-17(14)24-15(12-22-18)23-13-6-9-25(10-7-13)16(26)4-2/h4,11-13H,2-3,5-10H2,1H3,(H,20,27)(H,21,22)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM316773 (2-[(1-acryloylpiperidin-4-yl)amino]-N-butyl-5H-pyr...) Show SMILES CCCCNC(=O)c1c[nH]c2ncc(NC3CCN(CC3)C(=O)C=C)nc12 Show InChI InChI=1S/C19H26N6O2/c1-3-5-8-20-19(27)14-11-21-18-17(14)24-15(12-22-18)23-13-6-9-25(10-7-13)16(26)4-2/h4,11-13H,2-3,5-10H2,1H3,(H,20,27)(H,21,22)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM316773 (2-[(1-acryloylpiperidin-4-yl)amino]-N-butyl-5H-pyr...) Show SMILES CCCCNC(=O)c1c[nH]c2ncc(NC3CCN(CC3)C(=O)C=C)nc12 Show InChI InChI=1S/C19H26N6O2/c1-3-5-8-20-19(27)14-11-21-18-17(14)24-15(12-22-18)23-13-6-9-25(10-7-13)16(26)4-2/h4,11-13H,2-3,5-10H2,1H3,(H,20,27)(H,21,22)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...				US Patent US9617258 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZWG
					More data for this Ligand-Target Pair