BDBM317216 US9617272, Compound 27::US9981973, Compound 27
SMILES: O=C(CC1c2cncn2-c2ccccc12)C1CCCCC1
InChI Key: InChIKey=JYJDZMRPACDCEJ-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM317216 (US9617272, Compound 27 | US9981973, Compound 27) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
NewLink Genetics Corporation US Patent | Assay Description The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ... | US Patent US9617272 (2017) BindingDB Entry DOI: 10.7270/Q2HD7XQN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Homo sapiens (Human)) | BDBM317216 (US9617272, Compound 27 | US9981973, Compound 27) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The IC50 values for each compound were determined by testing the activity of TDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ... | J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2K35X00 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM317216 (US9617272, Compound 27 | US9981973, Compound 27) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ... | J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2K35X00 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Homo sapiens (Human)) | BDBM317216 (US9617272, Compound 27 | US9981973, Compound 27) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
NewLink Genetics Corporation US Patent | Assay Description The IC50 values for each compound were determined by testing the activity of TDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ... | US Patent US9617272 (2017) BindingDB Entry DOI: 10.7270/Q2HD7XQN | |||||||||||
More data for this Ligand-Target Pair |