null

SMILES: CCS(=O)(=O)c1ccc(CNC(=O)c2cnc3[C@H](C(C)C)N(Cc4ccc(Cl)cc4)C(=O)c3c2)cc1

InChI Key: InChIKey=PVVLHXCAUUVUNE-VWLOTQADSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 317856   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM317856 ((S)-6-(4-chlorobenzyl)-N-(4-(ethylsulfonyl)benzyl)...) Show SMILES CCS(=O)(=O)c1ccc(CNC(=O)c2cnc3[C@H](C(C)C)N(Cc4ccc(Cl)cc4)C(=O)c3c2)cc1 |r| Show InChI InChI=1S/C27H28ClN3O4S/c1-4-36(34,35)22-11-7-18(8-12-22)14-30-26(32)20-13-23-24(29-15-20)25(17(2)3)31(27(23)33)16-19-5-9-21(28)10-6-19/h5-13,15,17,25H,4,14,16H2,1-3H3,(H,30,32)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc. US Patent					Assay Description Compounds of the present invention were tested for ability to bind to RORγ in a cell-free competition assay with commercially available radio-li...				US Patent US9624217 (2017) BindingDB Entry DOI: 10.7270/Q29P33RJ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM317856 ((S)-6-(4-chlorobenzyl)-N-(4-(ethylsulfonyl)benzyl)...) Show SMILES CCS(=O)(=O)c1ccc(CNC(=O)c2cnc3[C@H](C(C)C)N(Cc4ccc(Cl)cc4)C(=O)c3c2)cc1 |r| Show InChI InChI=1S/C27H28ClN3O4S/c1-4-36(34,35)22-11-7-18(8-12-22)14-30-26(32)20-13-23-24(29-15-20)25(17(2)3)31(27(23)33)16-19-5-9-21(28)10-6-19/h5-13,15,17,25H,4,14,16H2,1-3H3,(H,30,32)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, LLC US Patent					Assay Description Compounds of the present invention were tested for ability to bind to RORγ in a cell-free competition assay with commercially available radio-li...				US Patent US10807980 (2020)
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM317856 ((S)-6-(4-chlorobenzyl)-N-(4-(ethylsulfonyl)benzyl)...) Show SMILES CCS(=O)(=O)c1ccc(CNC(=O)c2cnc3[C@H](C(C)C)N(Cc4ccc(Cl)cc4)C(=O)c3c2)cc1 |r| Show InChI InChI=1S/C27H28ClN3O4S/c1-4-36(34,35)22-11-7-18(8-12-22)14-30-26(32)20-13-23-24(29-15-20)25(17(2)3)31(27(23)33)16-19-5-9-21(28)10-6-19/h5-13,15,17,25H,4,14,16H2,1-3H3,(H,30,32)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, LLC US Patent					Assay Description Compounds of the present invention were tested for RORγ inverse agonist activity in a cell-based, transcriptional activity assay. Secreted Nanol...				US Patent US10807980 (2020)
					More data for this Ligand-Target Pair