BDBM3179 3-(3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl)guanidine::3-[1-(3-Guanidinopropyl)-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione Nitrate::Bisindolylmaleimide 13
SMILES: [#6]-n1cc(-[#6]-2=[#6](-[#6](=O)-[#7]-[#6]-2=O)-c2cn(-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])c3ccccc23)c2ccccc12
InChI Key: InChIKey=MFBWLCFHQHKTBP-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine)) | BDBM3179 (3-(3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Products Limited | Assay Description The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone. | J Med Chem 35: 994-1001 (1992) Article DOI: 10.1021/jm00084a004 BindingDB Entry DOI: 10.7270/Q2M043KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Kinase C (Rattus norvegicus (rat)) | BDBM3179 (3-(3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Products Limited | Assay Description The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his... | J Med Chem 35: 994-1001 (1992) Article DOI: 10.1021/jm00084a004 BindingDB Entry DOI: 10.7270/Q2M043KK | |||||||||||
More data for this Ligand-Target Pair |