null

SMILES: CC(C)[C@@H]1N(Cc2ccc(cc2)C(F)(F)F)Cc2cc(cnc12)C(=O)NCc1ccc(cc1)C#N

InChI Key: InChIKey=BCJDUIKKKZJSQZ-VWLOTQADSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 317911   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM317911 (US10399976, Compound 64 | US10807980, Compound 64 ...) Show SMILES CC(C)[C@@H]1N(Cc2ccc(cc2)C(F)(F)F)Cc2cc(cnc12)C(=O)NCc1ccc(cc1)C#N |r| Show InChI InChI=1S/C27H25F3N4O/c1-17(2)25-24-22(16-34(25)15-20-7-9-23(10-8-20)27(28,29)30)11-21(14-32-24)26(35)33-13-19-5-3-18(12-31)4-6-19/h3-11,14,17,25H,13,15-16H2,1-2H3,(H,33,35)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc. US Patent					Assay Description Compounds of the present invention were tested for ability to bind to RORγ in a cell-free competition assay with commercially available radio-li...				US Patent US9624217 (2017) BindingDB Entry DOI: 10.7270/Q29P33RJ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM317911 (US10399976, Compound 64 | US10807980, Compound 64 ...) Show SMILES CC(C)[C@@H]1N(Cc2ccc(cc2)C(F)(F)F)Cc2cc(cnc12)C(=O)NCc1ccc(cc1)C#N |r| Show InChI InChI=1S/C27H25F3N4O/c1-17(2)25-24-22(16-34(25)15-20-7-9-23(10-8-20)27(28,29)30)11-21(14-32-24)26(35)33-13-19-5-3-18(12-31)4-6-19/h3-11,14,17,25H,13,15-16H2,1-2H3,(H,33,35)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, LLC US Patent					Assay Description Compounds of the present invention were tested for ability to bind to ROR gamma in a cell-free competition assay with commercially available radio-li...				US Patent US10399976 (2019) BindingDB Entry DOI: 10.7270/Q2F76FXT
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM317911 (US10399976, Compound 64 | US10807980, Compound 64 ...) Show SMILES CC(C)[C@@H]1N(Cc2ccc(cc2)C(F)(F)F)Cc2cc(cnc12)C(=O)NCc1ccc(cc1)C#N |r| Show InChI InChI=1S/C27H25F3N4O/c1-17(2)25-24-22(16-34(25)15-20-7-9-23(10-8-20)27(28,29)30)11-21(14-32-24)26(35)33-13-19-5-3-18(12-31)4-6-19/h3-11,14,17,25H,13,15-16H2,1-2H3,(H,33,35)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds of the present invention were tested for ability to bind to RORγ in a cell-free competition assay with commercially available radio-li...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BK1H79
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM317911 (US10399976, Compound 64 | US10807980, Compound 64 ...) Show SMILES CC(C)[C@@H]1N(Cc2ccc(cc2)C(F)(F)F)Cc2cc(cnc12)C(=O)NCc1ccc(cc1)C#N |r| Show InChI InChI=1S/C27H25F3N4O/c1-17(2)25-24-22(16-34(25)15-20-7-9-23(10-8-20)27(28,29)30)11-21(14-32-24)26(35)33-13-19-5-3-18(12-31)4-6-19/h3-11,14,17,25H,13,15-16H2,1-2H3,(H,33,35)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, LLC US Patent					Assay Description Compounds of the present invention were tested for ability to bind to RORγ in a cell-free competition assay with commercially available radio-li...				US Patent US10807980 (2020) BindingDB Entry DOI: 10.7270/Q2PR803S
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM317911 (US10399976, Compound 64 | US10807980, Compound 64 ...) Show SMILES CC(C)[C@@H]1N(Cc2ccc(cc2)C(F)(F)F)Cc2cc(cnc12)C(=O)NCc1ccc(cc1)C#N |r| Show InChI InChI=1S/C27H25F3N4O/c1-17(2)25-24-22(16-34(25)15-20-7-9-23(10-8-20)27(28,29)30)11-21(14-32-24)26(35)33-13-19-5-3-18(12-31)4-6-19/h3-11,14,17,25H,13,15-16H2,1-2H3,(H,33,35)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, LLC US Patent					Assay Description Compounds of the present invention were tested for RORγ inverse agonist activity in a cell-based, transcriptional activity assay. Secreted Nanol...				US Patent US10807980 (2020) BindingDB Entry DOI: 10.7270/Q2PR803S
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM317911 (US10399976, Compound 64 | US10807980, Compound 64 ...) Show SMILES CC(C)[C@@H]1N(Cc2ccc(cc2)C(F)(F)F)Cc2cc(cnc12)C(=O)NCc1ccc(cc1)C#N |r| Show InChI InChI=1S/C27H25F3N4O/c1-17(2)25-24-22(16-34(25)15-20-7-9-23(10-8-20)27(28,29)30)11-21(14-32-24)26(35)33-13-19-5-3-18(12-31)4-6-19/h3-11,14,17,25H,13,15-16H2,1-2H3,(H,33,35)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, LLC US Patent					Assay Description Compounds of the present invention were tested for ROR gamma inverse agonist activity in a cell-based, transcriptional activity assay. Secreted Nanol...				US Patent US10399976 (2019) BindingDB Entry DOI: 10.7270/Q2F76FXT
					More data for this Ligand-Target Pair