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SMILES: CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2Br)CC1

InChI Key: InChIKey=CAHIWXFAYUQRIN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318009   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM318009 (2-[4-[(3-Bromo-2- pyridyl)methyl]piperazin-1- yl]-...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2Br)CC1 Show InChI InChI=1S/C18H23BrN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.9	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM318009 (2-[4-[(3-Bromo-2- pyridyl)methyl]piperazin-1- yl]-...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2Br)CC1 Show InChI InChI=1S/C18H23BrN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM318009 (2-[4-[(3-Bromo-2- pyridyl)methyl]piperazin-1- yl]-...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2Br)CC1 Show InChI InChI=1S/C18H23BrN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.58	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair