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SMILES: CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccn2)CC1

InChI Key: InChIKey=DBBRJAYFAWANIO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 318025   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM318025 (US9624218, Example 19 | US9624218, Example 34) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccn2)CC1 Show InChI InChI=1S/C18H24N6O/c1-22-8-4-6-15-16(22)20-18(21-17(15)25)24-11-9-23(10-12-24)13-14-5-2-3-7-19-14/h2-3,5,7H,4,6,8-13H2,1H3,(H,20,21,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19.9	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM318025 (US9624218, Example 19 | US9624218, Example 34) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccn2)CC1 Show InChI InChI=1S/C18H24N6O/c1-22-8-4-6-15-16(22)20-18(21-17(15)25)24-11-9-23(10-12-24)13-14-5-2-3-7-19-14/h2-3,5,7H,4,6,8-13H2,1H3,(H,20,21,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.8	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM318025 (US9624218, Example 19 | US9624218, Example 34) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccn2)CC1 Show InChI InChI=1S/C18H24N6O/c1-22-8-4-6-15-16(22)20-18(21-17(15)25)24-11-9-23(10-12-24)13-14-5-2-3-7-19-14/h2-3,5,7H,4,6,8-13H2,1H3,(H,20,21,25)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.62E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM318025 (US9624218, Example 19 | US9624218, Example 34) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccn2)CC1 Show InChI InChI=1S/C18H24N6O/c1-22-8-4-6-15-16(22)20-18(21-17(15)25)24-11-9-23(10-12-24)13-14-5-2-3-7-19-14/h2-3,5,7H,4,6,8-13H2,1H3,(H,20,21,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.6	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM318025 (US9624218, Example 19 | US9624218, Example 34) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccn2)CC1 Show InChI InChI=1S/C18H24N6O/c1-22-8-4-6-15-16(22)20-18(21-17(15)25)24-11-9-23(10-12-24)13-14-5-2-3-7-19-14/h2-3,5,7H,4,6,8-13H2,1H3,(H,20,21,25)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM318025 (US9624218, Example 19 | US9624218, Example 34) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccn2)CC1 Show InChI InChI=1S/C18H24N6O/c1-22-8-4-6-15-16(22)20-18(21-17(15)25)24-11-9-23(10-12-24)13-14-5-2-3-7-19-14/h2-3,5,7H,4,6,8-13H2,1H3,(H,20,21,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47.6	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair