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SMILES: CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C)CC1

InChI Key: InChIKey=WZAAURATTBNWBC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318030   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM318030 (8-Methyl-2-[4-(o- tolylmethyl)piperazin-1-yl]- 3,5...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C)CC1 Show InChI InChI=1S/C20H27N5O/c1-15-6-3-4-7-16(15)14-24-10-12-25(13-11-24)20-21-18-17(19(26)22-20)8-5-9-23(18)2/h3-4,6-7H,5,8-14H2,1-2H3,(H,21,22,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.2	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM318030 (8-Methyl-2-[4-(o- tolylmethyl)piperazin-1-yl]- 3,5...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C)CC1 Show InChI InChI=1S/C20H27N5O/c1-15-6-3-4-7-16(15)14-24-10-12-25(13-11-24)20-21-18-17(19(26)22-20)8-5-9-23(18)2/h3-4,6-7H,5,8-14H2,1-2H3,(H,21,22,26)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.74E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM318030 (8-Methyl-2-[4-(o- tolylmethyl)piperazin-1-yl]- 3,5...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C)CC1 Show InChI InChI=1S/C20H27N5O/c1-15-6-3-4-7-16(15)14-24-10-12-25(13-11-24)20-21-18-17(19(26)22-20)8-5-9-23(18)2/h3-4,6-7H,5,8-14H2,1-2H3,(H,21,22,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.2	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair