BDBM318042 2-[4-[(3-Chloropyrazin-2- yl)methyl]piperazin-l-yl]-8- methyl-3,5,6,7- tetrahydropyrido[2,3- d]pyrimidin-4-one::US9624218, Example 43
SMILES: CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccnc2Cl)CC1
InChI Key: InChIKey=SMUYIABTVDLDHO-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM318042 (2-[4-[(3-Chloropyrazin-2- yl)methyl]piperazin-l-yl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 34.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated... | US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM318042 (2-[4-[(3-Chloropyrazin-2- yl)methyl]piperazin-l-yl...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f... | US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM318042 (2-[4-[(3-Chloropyrazin-2- yl)methyl]piperazin-l-yl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated... | US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ | |||||||||||
More data for this Ligand-Target Pair |