BDBM31856 2,4-Bisanilinopyrimidine, 21

SMILES: Cc1nc(Nc2ccc(O)cc2)nc(Nc2ccc(O)cc2)c1C

InChI Key: InChIKey=XWIAAELWGFVDFU-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 31856   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM31856 (2,4-Bisanilinopyrimidine, 21) Show SMILES Cc1nc(Nc2ccc(O)cc2)nc(Nc2ccc(O)cc2)c1C Show InChI InChI=1S/C18H18N4O2/c1-11-12(2)19-18(21-14-5-9-16(24)10-6-14)22-17(11)20-13-3-7-15(23)8-4-13/h3-10,23-24H,1-2H3,(H2,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Genentech					Assay Description Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...				J Med Chem 52: 3300-7 (2009) Article DOI: 10.1021/jm9000314 BindingDB Entry DOI: 10.7270/Q2M90706
					More data for this Ligand-Target Pair