BDBM31867 2,4-Bisanilinopyrimidine, 33
SMILES: Cc1cccc(Nc2nc(Nc3ccc(O)cc3)ncc2F)c1
InChI Key: InChIKey=FKMCOGMATDCGOQ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Aurora kinase A (Homo sapiens (Human)) | BDBM31867 (2,4-Bisanilinopyrimidine, 33) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech | Assay Description Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the... | J Med Chem 52: 3300-7 (2009) Article DOI: 10.1021/jm9000314 BindingDB Entry DOI: 10.7270/Q2M90706 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) |