BDBM31867 2,4-Bisanilinopyrimidine, 33

SMILES: Cc1cccc(Nc2nc(Nc3ccc(O)cc3)ncc2F)c1

InChI Key: InChIKey=FKMCOGMATDCGOQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 31867   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM31867 (2,4-Bisanilinopyrimidine, 33) Show SMILES Cc1cccc(Nc2nc(Nc3ccc(O)cc3)ncc2F)c1 Show InChI InChI=1S/C17H15FN4O/c1-11-3-2-4-13(9-11)20-16-15(18)10-19-17(22-16)21-12-5-7-14(23)8-6-12/h2-10,23H,1H3,(H2,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Genentech					Assay Description Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...				J Med Chem 52: 3300-7 (2009) Article DOI: 10.1021/jm9000314 BindingDB Entry DOI: 10.7270/Q2M90706
					More data for this Ligand-Target Pair				3D Structure (docked)