null

SMILES: O=C1NCCCOc2ccc(=O)n(Cc3cccc(c3)C(=O)Nc3cn(nc13)C1CCOCC1)n2

InChI Key: InChIKey=WJPDPEBXKRAWLO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 318829   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM318829 (US10517872, Compound 6 | US9624246, Compound 6) Show SMILES O=C1NCCCOc2ccc(=O)n(Cc3cccc(c3)C(=O)Nc3cn(nc13)C1CCOCC1)n2 Show InChI InChI=1S/C24H26N6O5/c31-21-6-5-20-27-30(21)14-16-3-1-4-17(13-16)23(32)26-19-15-29(18-7-11-34-12-8-18)28-22(19)24(33)25-9-2-10-35-20/h1,3-6,13,15,18H,2,7-12,14H2,(H,25,33)(H,26,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Merck Patent GmbH US Patent					Assay Description IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK4 (1-460)). In this assay, IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Se...				US Patent US9624246 (2017) BindingDB Entry DOI: 10.7270/Q2DF6T92
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM318829 (US10517872, Compound 6 | US9624246, Compound 6) Show SMILES O=C1NCCCOc2ccc(=O)n(Cc3cccc(c3)C(=O)Nc3cn(nc13)C1CCOCC1)n2 Show InChI InChI=1S/C24H26N6O5/c31-21-6-5-20-27-30(21)14-16-3-1-4-17(13-16)23(32)26-19-15-29(18-7-11-34-12-8-18)28-22(19)24(33)25-9-2-10-35-20/h1,3-6,13,15,18H,2,7-12,14H2,(H,25,33)(H,26,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Patent GmbH US Patent					Assay Description IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK4 (1-460)).In this assay, IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Ser...				US Patent US10517872 (2019) BindingDB Entry DOI: 10.7270/Q2SN0CCS
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 [194-712] (Homo sapiens (Human))	BDBM318829 (US10517872, Compound 6 | US9624246, Compound 6) Show SMILES O=C1NCCCOc2ccc(=O)n(Cc3cccc(c3)C(=O)Nc3cn(nc13)C1CCOCC1)n2 Show InChI InChI=1S/C24H26N6O5/c31-21-6-5-20-27-30(21)14-16-3-1-4-17(13-16)23(32)26-19-15-29(18-7-11-34-12-8-18)28-22(19)24(33)25-9-2-10-35-20/h1,3-6,13,15,18H,2,7-12,14H2,(H,25,33)(H,26,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Merck Patent GmbH US Patent					Assay Description IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712))In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRAK...				US Patent US10517872 (2019) BindingDB Entry DOI: 10.7270/Q2SN0CCS
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 [194-712] (Homo sapiens (Human))	BDBM318829 (US10517872, Compound 6 | US9624246, Compound 6) Show SMILES O=C1NCCCOc2ccc(=O)n(Cc3cccc(c3)C(=O)Nc3cn(nc13)C1CCOCC1)n2 Show InChI InChI=1S/C24H26N6O5/c31-21-6-5-20-27-30(21)14-16-3-1-4-17(13-16)23(32)26-19-15-29(18-7-11-34-12-8-18)28-22(19)24(33)25-9-2-10-35-20/h1,3-6,13,15,18H,2,7-12,14H2,(H,25,33)(H,26,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Patent GmbH US Patent					Assay Description IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...				US Patent US9624246 (2017) BindingDB Entry DOI: 10.7270/Q2DF6T92
					More data for this Ligand-Target Pair