BDBM31889 BMS 961::BMS270394::BMS961
SMILES: CC1(C)CCC(C)(C)c2cc(ccc12)[C@@H](O)C(=O)Nc1ccc(cc1F)C(O)=O
InChI Key: InChIKey=AANFHDFOMFRLLR-LJQANCHMSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinoic Acid Receptor, gamma (Homo sapiens (Human)) | BDBM31889 (BMS 961 | BMS270394 | BMS961) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | 1.5 | -11.2 | n/a | n/a | n/a | n/a | n/a | 8.0 | 4 |
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) | Assay Description Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)... | Chem Biol 6: 519-29 (1999) Article DOI: 10.1016/S1074-5521(99)80084-2 BindingDB Entry DOI: 10.7270/Q2CV4G39 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Retinoic Acid Receptor, beta (Homo sapiens (Human)) | BDBM31889 (BMS 961 | BMS270394 | BMS961) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 7.9 | 4 |
CNRS | Assay Description Recombinant RAR protein expressed in E. coli was used in the direct binding assay. The apparent dissociation constants (Kd) were determined by the ch... | J Mol Biol 302: 155-70 (2000) Article DOI: 10.1006/jmbi.2000.4032 BindingDB Entry DOI: 10.7270/Q2BR8QHR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic Acid Receptor, gamma (Homo sapiens (Human)) | BDBM31889 (BMS 961 | BMS270394 | BMS961) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | n/a | 528 | n/a | n/a | n/a | 7.9 | 4 |
CNRS | Assay Description Recombinant RAR protein expressed in E. coli was used in the direct binding assay. The apparent dissociation constants (Kd) were determined by the ch... | J Mol Biol 302: 155-70 (2000) Article DOI: 10.1006/jmbi.2000.4032 BindingDB Entry DOI: 10.7270/Q2BR8QHR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Retinoic Acid Receptor, alpha (Homo sapiens (Human)) | BDBM31889 (BMS 961 | BMS270394 | BMS961) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 7.9 | 4 |
CNRS | Assay Description Recombinant RAR protein expressed in E. coli was used in the direct binding assay. The apparent dissociation constants (Kd) were determined by the ch... | J Mol Biol 302: 155-70 (2000) Article DOI: 10.1006/jmbi.2000.4032 BindingDB Entry DOI: 10.7270/Q2BR8QHR | |||||||||||
More data for this Ligand-Target Pair |