BDBM319094 N-[(cyclopropyl- carbamoyl) methyl]-2-{5- fluoro-6-[3-(1H- pyrazol-1-yl) phenyl]-1,3- benzothiazol- 2-yl}-2-(3,3,3- trifluoropropane- sulfonyl) acetamide::US10173991, Example 137
SMILES: Fc1cc2nc(sc2cc1-c1cccc(c1)-n1cccn1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCC(F)(F)F
InChI Key: InChIKey=OVOJKVZSHNBPEN-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endothelial lipase (Homo sapiens (Human)) | BDBM319094 (N-[(cyclopropyl- carbamoyl) methyl]-2-{5- fluoro-6...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi... | US Patent US10173991 (2019) BindingDB Entry DOI: 10.7270/Q2N018M8 | |||||||||||
More data for this Ligand-Target Pair |