BDBM319205 N-[(cyclopropyl- carbamoyl) methyl]-2-[5- fluoro-6-(2- methyl-1,3- benzothiazol-5- yl)-1,3- benzothiazol-2- yl]-2- methanesulfonyl- acetamide::US10173991, Example 248
SMILES: Cc1nc2cc(ccc2s1)-c1cc2sc(nc2cc1F)C(C(=O)NCC(=O)NC1CC1)S(C)(=O)=O
InChI Key: InChIKey=NZRHAGGBABXVRQ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endothelial lipase (Homo sapiens (Human)) | BDBM319205 (N-[(cyclopropyl- carbamoyl) methyl]-2-[5- fluoro-6...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi... | US Patent US10173991 (2019) BindingDB Entry DOI: 10.7270/Q2N018M8 | |||||||||||
More data for this Ligand-Target Pair |