BDBM319335 2-[6-(6- fluoropyridin- 3-yl)-1,3- benzothiazol- 2-yl]-2-(2- methoxyethane- sulfonyl)-N-{[(2- phenoxyethyl) carbamoyl]methyl} acetamide::US10173991, Example 380

SMILES: COCCS(=O)(=O)C(C(=O)NCC(=O)NCCOc1ccccc1)c1nc2ccc(cc2s1)-c1ccc(F)nc1

InChI Key: InChIKey=FUNCGECTVUTIRL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319335   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM319335 (2-[6-(6- fluoropyridin- 3-yl)-1,3- benzothiazol- 2...) Show SMILES COCCS(=O)(=O)C(C(=O)NCC(=O)NCCOc1ccccc1)c1nc2ccc(cc2s1)-c1ccc(F)nc1 Show InChI InChI=1S/C27H27FN4O6S2/c1-37-13-14-40(35,36)25(26(34)31-17-24(33)29-11-12-38-20-5-3-2-4-6-20)27-32-21-9-7-18(15-22(21)39-27)19-8-10-23(28)30-16-19/h2-10,15-16,25H,11-14,17H2,1H3,(H,29,33)(H,31,34)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...				US Patent US10173991 (2019) BindingDB Entry DOI: 10.7270/Q2N018M8
					More data for this Ligand-Target Pair