BDBM319472 2,2,2-trifluoroethyl N-{4-[2- ({[(cyclopropyl- carbamoyl)methyl] carbamoyl}(2- methoxyethane- sulfonyl)methyl)- 5-fluoro-1,3- benzothiazol-6- yl]phenyl} carbamate::US10173991, Example 526

SMILES: OCCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1ccc(NC(=O)OCC(F)(F)F)cc1

InChI Key: InChIKey=LILDUAKADHIBHB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319472   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM319472 (2,2,2-trifluoroethyl N-{4-[2- ({[(cyclopropyl- ca...) Show SMILES OCCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1ccc(NC(=O)OCC(F)(F)F)cc1 Show InChI InChI=1S/C26H26F4N4O7S2/c27-18-11-19-20(10-17(18)14-2-4-16(5-3-14)33-25(38)41-13-26(28,29)30)42-24(34-19)22(43(39,40)9-1-8-35)23(37)31-12-21(36)32-15-6-7-15/h2-5,10-11,15,22,35H,1,6-9,12-13H2,(H,31,37)(H,32,36)(H,33,38)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...				US Patent US10173991 (2019) BindingDB Entry DOI: 10.7270/Q2N018M8
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