BDBM319477 US10173991, Example 531::cyclopropylmethyl N-{4-[2- ({[(cyclopropyl- carbamoyl)methyl] carbamoyl}(3,3,3- trifluoropropane- sulfonyl)methyl)- 5-fluoro-1,3- benzothiazol- 6-yl]phenyl} carbamate

SMILES: Fc1cc2nc(sc2cc1-c1ccc(NC(=O)OCC2CC2)cc1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCC(F)(F)F

InChI Key: InChIKey=SGAZNPWDJKEIBP-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319477   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM319477 (US10173991, Example 531 | cyclopropylmethyl N-{4-...) Show SMILES Fc1cc2nc(sc2cc1-c1ccc(NC(=O)OCC2CC2)cc1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCC(F)(F)F Show InChI InChI=1S/C28H28F4N4O6S2/c29-20-12-21-22(11-19(20)16-3-5-18(6-4-16)35-27(39)42-14-15-1-2-15)43-26(36-21)24(44(40,41)10-9-28(30,31)32)25(38)33-13-23(37)34-17-7-8-17/h3-6,11-12,15,17,24H,1-2,7-10,13-14H2,(H,33,38)(H,34,37)(H,35,39)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...				US Patent US10173991 (2019) BindingDB Entry DOI: 10.7270/Q2N018M8
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