BDBM319483 US10173991, Example 539::propan-2-yl N-{4- [2-({[(cyclopropyl- carbamoyl)methyl] carbamoyl} (methanesulfonyl) methyl)-5-fluoro- 1,3-benzothiazol- 6-yl]phenyl} carbamate

SMILES: CC(C)OC(=O)Nc1ccc(cc1)-c1cc2sc(nc2cc1F)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CO

InChI Key: InChIKey=CRMFMOVIENYYGM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319483   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM319483 (US10173991, Example 539 | propan-2-yl N-{4- [2-({[...) Show SMILES CC(C)OC(=O)Nc1ccc(cc1)-c1cc2sc(nc2cc1F)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CO Show InChI InChI=1S/C25H27FN4O7S2/c1-13(2)37-25(34)29-16-5-3-14(4-6-16)17-9-20-19(10-18(17)26)30-24(38-20)22(39(35,36)12-31)23(33)27-11-21(32)28-15-7-8-15/h3-6,9-10,13,15,22,31H,7-8,11-12H2,1-2H3,(H,27,33)(H,28,32)(H,29,34)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...				US Patent US10173991 (2019) BindingDB Entry DOI: 10.7270/Q2N018M8
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