BDBM319494 US10173991, Example 550::benzyl N-{3-[2- ({[(cyclopropyl- carbamoyl)methyl] carbamoyl} (methanesulfonyl) methyl)-5-fluoro- 1,3-benzothiazol- 6-yl]phenyl} carbamate

SMILES: CS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1cccc(NC(=O)OCc2ccccc2)c1

InChI Key: InChIKey=HIZFCYTVWJEEHW-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319494   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM319494 (US10173991, Example 550 | benzyl N-{3-[2- ({[(cycl...) Show SMILES CS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1cccc(NC(=O)OCc2ccccc2)c1 Show InChI InChI=1S/C29H27FN4O6S2/c1-42(38,39)26(27(36)31-15-25(35)32-19-10-11-19)28-34-23-14-22(30)21(13-24(23)41-28)18-8-5-9-20(12-18)33-29(37)40-16-17-6-3-2-4-7-17/h2-9,12-14,19,26H,10-11,15-16H2,1H3,(H,31,36)(H,32,35)(H,33,37)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...				US Patent US10173991 (2019) BindingDB Entry DOI: 10.7270/Q2N018M8
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